Protein Details: Potassium channel subfamily K member 10

Protein ID

ICDB_Pro_0639

Protein Name

Potassium channel subfamily K member 10

Gene Name

KCNK10; TREK2

Organism

Homo sapiens (Human)

Length

538 amino acids

AlphaFoldDB

AF-P57789-F1-model_v4.pdb

Function

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

Sequence

MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN

PDB Structures

4BW5 4XDJ 4XDK 4XDL

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Birk-Barel Syndrome and Spinocerebellar Ataxia;X-Linked 2

Location

Abundantly expressed in pancreas and kidney and to a lower level in brain;testis;colon;and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas;whereas isoform c is abundantly expressed in brain.

DOI ID

10.1074/jbc.m002822200; 10.1113/jphysiol.2001.013432; 10.1038/bjp.2008.213; 10.1038/ng1285; 10.1038/nature01348; 10.1101/gr.2596504

RefSeq

NP_066984.1 [P57789-1]; NP_612190.1 [P57789-3]; NP_612191.1 [P57789-4]